Suppression of ADP-ribosylation reversal triggers cell vulnerability to alkylating agents
This study investigates how the suppression of ADP-ribosyl inversion enhances the vulnerability of cancer cells.
Articles, insights and updates on biochemistry and biomedical research, with a focus on scientific innovation, healthcare technologies, and the application of artificial intelligence in medical and biological fields.
Exploitation of DarT/DarG biology for a rational design of antimicrobial agents
Let's discuss the structure and mechanistic aspects of toxin- and antitoxin-mediated control, as well as therapeutic prospects.
The DarT/DarG Toxin-Antitoxin ADP-Ribosylation System as a Novel Target for a Rational Design of Innovative Antimicrobial Strategies
In this perspective, we discuss the structural and mechanistic aspects of DarT/DarG toxin–antitoxin-mediated control of DNA ADP-ribosylation. In addition, we then address the pathogenic role of the DarT/DarG TA pair as well as the therapeutic perspectives that the modulation of this specific ADP-ribosylation signalling may have.
Fasting Drivers Nrf2-Related Antioxidant Response in Skeletal Muscle
We demonstrate the positive role of fasting as a protective mechanism against oxidative stress in skeletal muscle.
Estrogen Induces Selective Transcription of Caveolin1 Variants in Human Breast Cancer through Estrogen Responsive Element-Dependent Mechanisms
In this study, we dissect the molecular mechanism involved in selective expression of CAV1β isoform, induced by estrogens and downregulated in breast cancer.
microRNA-949 Favors H0-1 Expression in Neuroblastoma Cells Exposed to Oxidative Stress in a Bach1-Independent Way
Our findings highlight the role of miR-494 in promoting HO-1 induction and cellular adaptation to oxidative stress, and contribute to the discovery of new potential drug targets for improving cancer therapies.
Y0-4-Molecular mechanisms of H0-1 up-regulation in neuroblastoma cell responde to oxidative stress
In this study, we evaluated the involvement of the molecular mechanisms of HO-1 induction in NB cell response to OS, analyzing its main activator Nrf2 and its main repressor Bach1.
P-182-miRNA494 downregulation increases neuroblastoma sensivity to oxidative stress
Neuroblastoma cells (NB) are able to counteract oxidative stress (OS) through the activation of antioxidant defense mechanisms among which Nrf2/HO-1 system plays a crucial role.
miR-128 Is Implicated in Stress Responses by Targetng MAFG in SKeletal Muscle Cells
Abstract MAFG (v-Maf avian musculoaponeurotic fibrosarcoma oncogene homolog G) is a bZIP-type transcriptional regulator that belongs to the small MAF (sMAFs) protein family. By interacting with other bZIP transcription factors, sMAFs can form homo- and heterodimers governing either repressive or activating transcriptional functions.…
Nrf2 Pathway in Age-Related Neurological Disorders: Insights into MicroRNAs
Current clinical research aims to determine whether known natural compounds can prevent or improve degenerative conditions.
