Suppression of ADP-ribosylation reversal triggers cell vulnerability to alkylating agents
This study investigates how the suppression of ADP-ribosyl inversion enhances the vulnerability of cancer cells.... Read more.
Exploitation of DarT/DarG biology for a rational design of antimicrobial agents
Let's discuss the structure and mechanistic aspects of toxin- and antitoxin-mediated control, as well as therapeutic prospects.... Read more.
The DarT/DarG Toxin-Antitoxin ADP-Ribosylation System as a Novel Target for a Rational Design of Innovative Antimicrobial Strategies
In this perspective, we discuss the structural and mechanistic aspects of DarT/DarG toxin–antitoxin-mediated control of DNA ADP-ribosylation. In addition, we then... Read more.
Fasting Drivers Nrf2-Related Antioxidant Response in Skeletal Muscle
We demonstrate the positive role of fasting as a protective mechanism against oxidative stress in skeletal muscle.... Read more.
Estrogen Induces Selective Transcription of Caveolin1 Variants in Human Breast Cancer through Estrogen Responsive Element-Dependent Mechanisms
In this study, we dissect the molecular mechanism involved in selective expression of CAV1β isoform, induced by estrogens and downregulated in breast cancer.... Read more.
microRNA-949 Favors H0-1 Expression in Neuroblastoma Cells Exposed to Oxidative Stress in a Bach1-Independent Way
Our findings highlight the role of miR-494 in promoting HO-1 induction and cellular adaptation to oxidative stress, and contribute to the discovery of new potential... Read more.
Y0-4-Molecular mechanisms of H0-1 up-regulation in neuroblastoma cell responde to oxidative stress
In this study, we evaluated the involvement of the molecular mechanisms of HO-1 induction in NB cell response to OS, analyzing its main activator Nrf2 and its main... Read more.
P-182-miRNA494 downregulation increases neuroblastoma sensivity to oxidative stress
Neuroblastoma cells (NB) are able to counteract oxidative stress (OS) through the activation of antioxidant defense mechanisms among which Nrf2/HO-1 system plays... Read more.
miR-128 Is Implicated in Stress Responses by Targetng MAFG in SKeletal Muscle Cells
Abstract MAFG (v-Maf avian musculoaponeurotic fibrosarcoma oncogene homolog G) is a bZIP-type transcriptional regulator that belongs to the small MAF (sMAFs) protein... Read more.
Nrf2 Pathway in Age-Related Neurological Disorders: Insights into MicroRNAs
Current clinical research aims to determine whether known natural compounds can prevent or improve degenerative conditions.... Read more.
