Suppression of ADP-ribosylation reversal triggers cell vulnerability to alkylating agents
Questo studio indaga come la soppressione della inversione ADP-ribosilazione migliori la vulnerabilità delle cellule tumorali agli agenti alchilanti.... Leggi tutto.
Exploitation of DarT/DarG biology for a rational design of antimicrobial agents
Antibiotic resistant “superbugs” represent a major public health concern of the last 21th century, with an expected number of ten million deaths per... Leggi tutto.
The DarT/DarG Toxin-Antitoxin ADP-Ribosylation System as a Novel Target for a Rational Design of Innovative Antimicrobial Strategies
Abstract The chemical modification of cellular macromolecules by the transfer of ADP-ribose unit(s), known as ADP-ribosylation, is an ancient homeostatic and stress... Leggi tutto.
