The DarT/DarG Toxin-Antitoxin ADP-Ribosylation System as a Novel Target for a Rational Design of Innovative Antimicrobial Strategies
In this perspective, we discuss the structural and mechanistic aspects of DarT/DarG toxin–antitoxin-mediated control of DNA ADP-ribosylation. In addition, we then address the pathogenic role of the DarT/DarG TA pair as well as the therapeutic perspectives that the modulation of this specific ADP-ribosylation signalling may have.
